Living in Clifton, Bristol from 1798 to 1799, he knew Thomas Beddoes and Humphry Davy, and frequented the Pneumatic Institute. Roget then attended lectures at London medical schools. Samuel Romilly, who had supported his education, also introduced Roget into Whig social circles. After his father's death, the family moved to Edinburgh, in 1793, and he shortly began to study medicine at the University of Edinburgh, graduating in 1798. Peter Mark Roget was born in Broad Street, Soho, London, the son of Jean (John) Roget (1751–1783), a Genevan cleric, and his wife Catherine Romilly, sister of Samuel Romilly.
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